John Jeffrey, Chairman of Scottish Rugby and former teammate of Doddie Weir said: “Doddie was ahead of his time as a ball playing second row and for almost a decade he was one of the first names on the Scotland team sheet. He was a great team mate on the pitch and an even greater team mate off the pitch.

“In rugby terms Doddie will probably be remembered for two things, the cruel injury in South Africa which prevented him winning a deserved Lions Test cap and Bill McLaren describing him as a mad giraffe (which he loved!).

“This does not do justice to his rugby playing abilities where he was one of the most sought after signings at the start of the professional era.

“For all that Doddie achieved as a rugby player, his name is associated worldwide with the battle to find a cure for MND.

“For the last six years, Doddie and Kathy have dedicated themselves to not only finding a cure for MND but also caring for fellow sufferers. He raised literally millions for his foundation but, more importantly, raised awareness globally as he courageously battled this cruel disease, and always with a smile on his face.

“Our thoughts are with Kathy and the boys as we remember the great life of Doddie Weir.”

Scottish Rugby statement: “We are truly saddened to hear of Doddie’s passing today and we send our love and condolences to Kathy, Ben, Hamish and Angus at this time.

“Doddie carried the determination and drive he had as a successful player into his fight against Motor Neuron Disease. He tackled it with humour, with dignity and selflessly as he raised vital funding and awareness of the condition.

“With his actions Doddie has both humbled and inspired us and many others. He was the very best of us and will be sorely missed.”