There is also a return to the 23-player squad for Francesca McGhie and Rachel McLachlan, who take their place amongst the replacements.
Wills replaces Emma Orr, who will miss the rest of the Championship through injury, and will line up at outside centre alongside Meryl Smith at inside centre.
After scoring her first try for Scotland last weekend, Shona Campbell retains her place on the left wing. Rhona Lloyd starts on the right, with Chloe Rollie – who scored the first try of the Fukofuka era – at full-back to make up the back three.
Leia Brebner-Holden will start at scrum-half with Helen Nelson featuring outside her at stand-off fresh from a player-of-the-match performance at the Principality Stadium.
The forward pack remains unchanged as loosehead proper Leah Bartlet is joined in the front row with Lana Skeldon at hooker and Elliann Clark at tighthead.
In the second row, Hollie Cunningham and Emma Wassell continue their partnership. Last weekend’s debutant Emily Coubrough keeps the number 8 shirt, with captain Rachel Malcolm leading from blindside flanker and partnered with Alex Stewart on the openside.
The forward replacements are front rows Elis Martin, Demi Swann and Molly Poolman, second row Holland Bogan and back row McLachlan.
McGhie, Rianna Darroch and Lucia Scott, who bagged our third and final try against Wales, will be the backs available from the bench.
Be a part of a record-breaking crowd at Scottish Gas Murrayfield and get your tickets for Scotland Women vs England here.
Scotland Women team to face England in the 2026 Guinness Women’s Six Nations at Scottish Gas Murrayfield on Saturday 18 April kick-off 1.30pm – live on BBC Two (caps in brackets).
15. Chloe Rollie – Toulon Provence Méditerranée (82)
14. Rhona Lloyd – Sale Sharks (63)
13. Evie Wills – Sale Sharks (9)
12. Meryl Smith – Bristol Bears (23)
11. Shona Campbell – Sale Sharks (10)
10. Helen Nelson – Vice-Captain – Loughborough Lightning (76)
9. Leia Brebner-Holden – Loughborough Lightning (16)
1. Leah Bartlett – Sale Sharks (50)
2. Lana Skeldon – Bristol Bears (85)
3. Elliann Clarke – Bristol Bears (25)
4. Emma Wassell – Trailfinders Women (73)
5. Hollie Cunningham – Bristol Bears (3)
6. Rachel Malcolm – Captain – Trailfinders Women (62)
7. Alex Stewart – Edinburgh Rugby/University of Edinburgh (18)
8. Emily Coubrough – Glasgow Warriors/University of Edinburgh (1)
Replacements
16. Elis Martin – Loughborough Lightning (27)
17. Demi Swann – Exeter Chiefs (1)
18. Molly Poolman – Edinburgh Rugby/Watsonian FC (8)
19. Holland Bogan – Glasgow Warriors/Stirling County (1)
20. Rachel McLachlan – Montpellier (56)
21. Rianna Darroch – Glasgow Warriors/Hillhead Jordanhill (uncapped)
22. Lucia Scott – Loughborough Lightning (8)
23. Francesca McGhie – Trailfinders Women (26)